Investigation of the novel G protein heterodimer; the G β5 ‐RGS7 complex
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چکیده
منابع مشابه
Fidelity of G protein b-subunit association by the G protein g-subunit-like domains of RGS6, RGS7, and RGS11
Several regulators of G protein signaling (RGS) proteins contain a G protein g-subunit-like (GGL) domain, which, as we have shown, binds to Gb5 subunits. Here, we extend our original findings by describing another GGLdomain-containing RGS, human RGS6. When RGS6 is coexpressed with different Gb subunits, only RGS6 and Gb5 interact. The expression of mRNA for RGS6 and Gb5 in human tissues overlap...
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GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes
The extent and temporal characteristics of G protein-coupled receptor (GPCR) signaling are shaped by the regulator of G protein signaling (RGS) proteins, which promote G protein deactivation. With hundreds of GPCRs and dozens of RGS proteins, compartmentalization plays a key role in establishing signaling specificity. However, the molecular details and mechanisms of this process are poorly unde...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.5.a916-d